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Project Supervisors: Professor Janna Morrison, and Dr Sally Plush Project Summary: Lipid metabolic and biosynthetic pathways are implicated in a wide range of chronic diseases. Maternal diet can have a significant impact on how lipids are metabolised by offspring, and subsequently their health in later life. However, the exact mechanisms behind this are Aspirin and Omeprazole Tablets (Yosprala)- Multum unknown.

Methods for measuring and localising lipids in tissue can provide insight into how factors, such as maternal overnutrition, result in changes to lipid profile in the fetus. This project explores methods for analysing lipids in sheep tissue, for example epifluorescence and confocal microscopy, and high-performance liquid chromatography (HPLC), and will expose students to various laboratory techniques and analytical methods.

Students will have the opportunity to gain skills in histology and tissue sample preparation, image acquisition and data analysis. Our people Our Researchers Professor Janna Morrison And alcohol antibiotics Early Origins of Adult Health Research Group Dr Jack Darby Dr Ashley Meakin Stacey Holman Emma Bradshaw Megan Quinn Sarah Jesse And alcohol antibiotics researchers minus-thick plus-thick Eric Schrauben Research Fellow, Translational Medicine, And alcohol antibiotics for Sick Children, Toronto, Canada My background is MRI acquisition, image reconstruction, and data analysis for blood flow assessment.

Recent publications Schrauben, E. Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance and alcohol antibiotics fetal sheep. Journal of Cardiovascular Magnetic Resonance, 21(1), p. Fetal exinef 4D imaging using motion-corrected multi-planar real-time MRI.

Magn Reson Med 2019;82(3):1055-1072. Macdonald JA, Corrado PA, Nguyen SM, Johnson KM, Francois CJ, Magness RR, Shah DM, Golos TG, Wieben O. Uteroplacental and Fetal 4D Flow MRI in the Pregnant Rhesus Macaque. J Magn Reson Imaging 2019;49(2):534-545. Haris K, Hedstrom E, Kording F, Bidhult S, Steding-Ehrenborg K, Ruprecht C, Heiberg E, And alcohol antibiotics H, Aletras AH. Free-breathing fetal cardiac MRI with doppler ultrasound gating, compressed sensing, and motion compensation. J Magn Reson Imaging 2019.

Kolbitsch C, Bastkowski R, Carrier oil T, Prieto Vasquez C, Weiss K, Maintz D, Giese D. Respiratory motion corrected 4D flow using golden radial phase encoding. Magn Reson Med 2019. And alcohol antibiotics R, Weiss Indications for biopsy, Maintz D, Giese D. Self-gated golden-angle spiral 4D flow MRI. Magn Reson Med 2018;80(3):904-913.

Current Postgraduate students Catherine Dimasi PhD Candidate, Early Origins of Adult Health Research Group The aim of my research is to understand how genes and miRNAs can regulate proliferation of cardiomyocytes during pregnancy and in post-natal life.

Soo, Jia Yin Brooks, And alcohol antibiotics A. Seed, Mike Selvanayagam, Joseph B. Identification of Novel miRNAs Involved in Cardiac Repair Following Infarction in Fetal and Adolescent Sheep And alcohol antibiotics. Regulation of microRNA during cardiomyocyte maturation in sheep.

BMC genomics, 16(1), 541. Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine. J Physiol, 597: 2163-2176. Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression. Multidimensional fetal flow imaging with cardiovascular magnetic resonance: a feasibility study. Journal of Cardiovascular Magnetic Resonance, 20(1), p. Assessment of uterine artery geometry and hemodynamics in human pregnancy with 4d flow mri and its correlation with doppler ultrasound.

Ludwig bayer of Magnetic Resonance Imaging, 49(1), pp. Uteroplacental and fetal 4D flow MRI in the pregnant rhesus macaque. Journal of Magnetic Resonance Imaging, 49(2), pp. Fetal whole-heart 4D flow cine MRI using multiple non-coplanar balanced SSFP stacks. J Biochem Mol Toxicol, 2007. Riley, Clinical management of medications in pregnancy and alcohol antibiotics lactation.

Am J Obstet Gynecol, 2016. J Matern Fetal Neonatal Med, 2014: p. Varner, Principles of pharmacokinetics in the pregnant women and fetus. Ornoy, The role of the abbvie nyse abbv in drug transport and fetal drug exposure.

Expert Rev Clin Pharmacol, 2018. Cerebral oxygenation of premature lambs supported by an artificial placenta. Asaio Journal, and alcohol antibiotics, pp. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Cerebral oxygen delivery is reduced in and alcohol antibiotics with congenital heart disease.

The Journal of thoracic and cardiovascular surgery, 152(4), pp. Magnetic resonance in medicine, 78(6), pp. MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease. Prenatal diagnosis, 36(3), pp.



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